William Lowry, PhD
Assistant Professor Department of Molecular, Cell, & Developmental Biology

Adult stem cells are set aside during development in order to provide a source for replenishment of tissue over time in response to damage or simply wear and tear. The literature suggests that stem cells can be found in most major organ systems, and that they possess defining characteristics, namely the ability to both self-renew and differentiate down one or more specific lineages. Many groups have sought to define stem cell specific physiology in a molecular fashion by identifying those genes specifically expressed in stem cells. These data suggest that there are genes frequently found to be upregulated in stem cells from various tissues, but these data do not definitively demonstrate that these cells all function similarly. There is also considerable data showing that various signaling pathways influence stem cell growth and differentiation. A review of this literature suggests that many well-described pathways affect adult mammalian stem cells from different tissues similarly, and that these effects are sometimes unique to stem cells as opposed to their progeny. We investigate whether stem cells found in different tissues utilize similar mechanisms to undergo self-renewal and differentiation. Only by understanding self-renewal and differentiation can we hope to make inroads into the "cancer stem cell" hypothesis and potentially take advantage of their inherent plasticity. To explore whether similar mechanisms are employed by stem cells during both adult tissue homeostasis and embryonic development, Dr. Lowry's laboratory is also working to understand how the earliest steps of lineage restriction/decision are made in the embryo where ectodermal cells become either neuronal or epidermal. He hopes to put the knowledge gained by studying adult stem cells to clinical use.

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UCLA ACCESS
Jonsson Comprehensive Cancer Center