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The Broad Foundation Donates $20 Million The Eli and Edythe Broad Foundation is donating $20 million to fund adult and embryonic stem cell research at UCLA, enhancing a program that brings together biologists, chemists, engineers, geneticists and other scientists to develop new and more effective treatments for cancer, HIV/AIDS, Parkinson’s, metabolic disorders and other medical conditions. In recognition of the gift, the Institute for Stem Cell Biology and Medicine at UCLA will be renamed the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. The gift will be used to purchase specialized, high-tech laboratory equipment and will support faculty recruitment through research grants and endowed professorships, enabling UCLA to continue its leadership in cutting-edge, multidisciplinary scientific and medical research. READ MORE.... For pictures and video of the ceremony... 2009 Drs. Don Kohn, Irvin Chen, and Dennis Slamon were awarded $49.2 million in CIRM grants for bench to bedside research in sickle cell disease, HIV/AIDS, and ovarian, colorectal, and brain cancers. READ MORE.... hESC and iPSC are distinguished by gene expression. BSCRC faculty Drs. William Lowry and Kathrin Plath, and their associates found that human embryonic stem cells and skin cells reprogrammed into embryonic-like cells have inherent molecular differences, demonstrating for the first time that the two cell types are clearly distinguishable from one another. The data, pulished in Cell Stem Cell, suggest that embryonic stem cells and the reprogrammed cells, known as induced pluripotent stem (iPS) cells, have overlapping but still distinct gene expression signatures. Cell Stem Cell. Read more.... BSCRC member
Dr. William Lowry and associates showed for the first time that human induced pluripotent stem cells (iPSC) can be differentiated into electrically active motor neurons. The discovery may aid in studying and treating neurological disorders.The research appeared in the early online edition of the journal Stem Cells. Read the story... UCLA Broad Stem Cell Research Center received $3.93M from the California Institute of Regenerative Medicine (CIRM) to renew a grant to train young scientists to conduct stem cell research. The three-year competitive grant will fund the training of 16 graduate students, post-doctoral fellows and physicians conducting stem cell research per year. CIRM training grant funding to UCLA now totals $7.68M, the largest amount awarded to a stem cell center. Read the story... 2008 Dr. Zoran Galic, et.al., developed a generation of T lineage cells from human embryonic stem cells (hESC) in a feeder free system. The paper demonstrates that T cells can be differentiated from hESC in a system free of animal based support cells. The research suggests that hESC may have the potential to reconstitute the T cell arm of the immune system, or as a vehicle for gene therapeutic approaches to augment T cell immunity enabling their use in clinical work targeting cures for various diseases such as AIDS. Read the article... Dr. Amander Clark and associates identified a transcriptional signature associated with malignant cancer stem cell emergence in testicular cancer. The findings may lead to the development of a strategy to prevent malignant transformation in testicular cancer and preserve testicular tissue in order to ensure reproductive health in men diagnosed with this disease. Additionally, the research may lead to the development of strategies to minimize metastasis in men who present with the late stage or treatment resistance disease. Read the article... CIRM awards UCLA scientists, Drs. Brigitte Gomperts and Antoni Ribas, $5.45 million in grants to conduct leading-edge research that may shed light on the role of stem cells in the development of lung cancer and help to create a cancer-fighting immune system. Drs. Gomperts and Ribas were among 23 researchers from throughout the state chosen to receive New Faculty Awards, designed to encourage and foster the next generation of stem cell researchers. Drs. Amander Clark and Jerome Zack each received grants from the California Institute for Regenerative Medicine (CIRM) to create new pluripotent human stem cell lines that may one day help scientists better understand, diagnose and treat serious injury and disease. READ MORE... Director Owen Witte and colleagues received a $2.25 million grant to study prostate cancer stem cells and better define the role they play in cancer development, drug resistance and disease recurrence. UCLA was one of eight groups chosen from a nationwide pool of more than 100 proposals by the Prostate Cancer Foundation to receive a 2008 Challenge Award. Hong Wu and BSCRC Investigators identified a type of leukemia stem cell and uncovered the molecular and genetic mechanisms that cause a normal blood stem cells to become cancerous. The discovery may lead to new therapies that target these leukemia stem cells, attacking the disease at its very root and killing the early cells that give rise to the mature cancer cells. The study appears in the May 22, 2008 issue of the journal Nature: read more online..... BSCRC receives ~$20 million grant to create stem cell laboratories and innovative core resources to support basic to translational stem cell research. UCLA BSCRC Investigators Create Heart and Blood Cells fro Reprogrammed Skin Cells Broad Stem Cell Research Center Investigators Identify Genetic Differences in hESC that could Control Individual Traits and Disease Susceptability READ MORE: Stem Cell: online Mar 27, 2008. UCLA scientist Hanna Mikkola, MD, PhD, reports blood stem cells originate and are nurtured in the placenta (March 5, 2008) Broad Stem Cell Center Researchers Reprogram Human Skin Cells Into Cells with the same Properties as Human Embryonic Stem Cells (February 11, 2008) Broad Stem Cell Center Researcher Uncovers Unique Reglatory Mechanism of Gene Expression in Mouse Embryonic Stem Cells (February 7, 2007) The article is published in Cell Stem Cell, v2, n2: February 7, 2008. 2007 Three UCLA Scientists Receive Stem Cell Grants Totaling $7.5 million (December 12, 2007) UCLA Scientist Kathrin Plath wins prestigious NIH New Innovator Award from among 2,100 applicants nationwide (September 18, 2007) More information... ISCBM scientists produce a large quantity of highly pure functioning neurons from human embryonic stem cells (August 13, 2007). READ MORE: PNAS ARTICLE... ISCBM Stem Cell Researchers Reprogram Normal Tissue Cells into Cells with the Same Properties as Embryonic Stem Cells (June 6, 2007) Hear Dr. Plath discuss her research on KPPC 89.3 FM "Air Talk". UCLA Stem Cell Institute Receives $2.86 Million Grant from the State to Create New Stem Cell Laboratory Space (June 5, 2007) READ MORE... ISCBM Scientists Awarded More Than $5 Million in CIRM Comprehensive Grants ISCBM Scientists Awarded More Than $4 Million in CIRM Seed Grants (February 19, 2007): 2006 ISCBM ADDS FIVE INTERNATIONALLY RENOWNED SCIENTISTS TO ITS RESEARCH TEAM ISCBM Researcher Finds Neural Stem Cells Grown in the Laboratory are Inferior to those taken from Donated Fetal Tissue: July 26, 2006 Human Molecular Genetics. Associated Press Showcases ISCBM July 24, 2006 UCLA Researchers Transform Stem Cells Found in Human Fat Into Smooth Muscle Cells UCLA NEWS 4/10/06: UCLA Medicine, Winter 2006 UCLA Magazine, January 2006 UCLA News 1/24/06 2005 The Journal of Clinical Investigations, v115, n11 November 2005 UCLA College Report, Summer 2005 Vol. 4 Jonsson Cancer Center Foundation News, Spring/Summer 2005 UCLA News 9/12/2005 UCLA News 3/16/2005
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